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. Author manuscript; available in PMC: 2012 Jun 25.
Published in final edited form as: Oncogene. 2011 Mar 14;30(30):3328–3335. doi: 10.1038/onc.2011.57

Figure 2.

Figure 2

Knockdown of TRIB2 by shRNA inhibits cell proliferation and abrogates tumor growth. (a) Western blot of TRIB2 expression in U937 cells infected with sh1 or sh2. Actin is shown as a loading control. *Bands likely represent an alternate isoform of TRIB2. (b) Relative cell proliferation in H226 cells infected with sh1 or sh2. Values are expressed relative to cell number on day 0. *P<0.01 by Student’s t-test relative to non-targeting controls. (c) Tumor growth in NOD/SCID mice injected with 50 000 H226 cells infected (or mock infected) with the indicated shRNA construct directed against TRIB2. Animals were killed once tumor volume reached 1000mm3. Shown is a representative experiment (n=8). Error bars represent standard deviation.