Figure 1.

EPO protection in CTX-induced muscle injury and repair in vivo. A, B) Total body mass (A) and lean body mass (B) were determined for TgEpoR, tg6, and WT littermate mice at 4 wk of age (sex matched, n=6). C) Representative sections of gastrocnemius muscles from WT mice harvested at 7 d after PBS treatment (100 μl), treatment with PBS containing CTX (WT+CTX; 10 μM), and treatment with CTX plus EPO (WT+CTX+EPO; 3000 U/kg), and stained for hematoxylin and eosin (H&E), Evans blue dye (red), and Pax-7 (green). For Evans blue dye uptake, at 24 h prior to tissue collection, Evans blue dye solution (1%) was injected intraperitoneally.