Table 2.
SNPs in HMOX1 and HMOX2 associated with decreased influenza vaccine response as measured by median (IQR) HI antibody titer in normal human subjects (n=147 total)
| SNP | Chr | Gene | Major allele | Minor allele | 0 minor alleles | 1 minor alleles | 2 minor alleles | P |
|---|---|---|---|---|---|---|---|---|
| rs743811 | 22 | HMOX1 | A | G | 160 (80, 320) | 80 (60, 160) | 20 (20, 20) | 0.017* |
| [n=77] | [n=58] | [n=12] | ||||||
| rs2160567 | 16 | HMOX2 | A | G | 160 (80, 320) | 80 (60, 160) | 20 (20, 20) | 0.014* |
| [n=62] | [n=71] | [n=14] |
HMOX1, heme oxygenase 1; HMOX2, heme oxygenase 2; chr, chromosome.
*
P ≤ 0.05; ordinal effects model.