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. 2012 Jul;26(7):2986–2999. doi: 10.1096/fj.12-204495

Figure 1.

Figure 1.

Muscle sparing in MuRF1-KO but not MAFbx-KO mice. A) Representative muscle cross section from the TA muscle of WT, MuRF1-KO, and MAFbx-KO mice taken after 28 d of denervation. Muscle cross sections were stained with hematoxylin and eosin and show muscle fiber degeneration (arrows), primarily in the MAFbx-KO mice. B) Muscle mass, expressed as relative wet weight (denervated/control), is plotted for the TS complex (solid bars) and TA (open bars) muscles following 28 d of denervation. Data are expressed as means ± sd of muscles from WT (n=10), MuRF1-KO (n=7), and MAFbx-KO (n=7) mice. C) Muscle mass, expressed as relative wet weight (denervated/control), is plotted for the TS complex following 3 d (solid bars) and 14 d (open bars) of denervation. Data are means ± sd of muscles from WT (n=5–7/time point) and MuRF1-KO (n=7–8/time point) mice. *P < 0.05 vs. WT denervated muscle.