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. 2012 Jul;26(7):2868–2876. doi: 10.1096/fj.11-200923

Figure 5.

Figure 5.

PrPSc deposits vary in the brains of WT and Tg(MoPrP167S)82 mice infected with RML mouse prions. A) In a WT mouse, diffuse PrPSc aggregates are distributed throughout the hippocampus (top panel, h) and striatum (bottom panel, s) with less PrPSc in the corpus callosum (top panel, cc). In contrast, brain from a Tg(MoPrP167S)82 mouse shows diffuse and dense aggregates in the hippocampus and corpus callosum (top panel) and dense punctuate aggregates in the striatum. B) Only RML prion-infected Tg(MoPrP167S)82 mice developed plaques that bind PTAA. Positive control is from an RML prion-infected transgenic mouse expressing glycosylphosphatidylinositol-anchorless PrP. Scale bars = 200 μm (A); 15 μm (B).