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Isolated and perfused Langendorff rat heart. Dose-dependent response curves of serpinin Ala26Leu (1 to 165 nM) on HR; myocardial parameters LVP, RPP, and +(LVdP/dt)max; and lusitropic parameters −(LVdP/dt)max, T/−T, and CP on Langendorff perfused rat heart preparation. See Results for basal values. Percentage changes were evaluated as means ± se of 7 experiments. *P < 0.05 vs. control; 1-way ANOVA.
