Table 2. Blood plasma profile after DOX treatment.

Model	Treatment	CK (U/L)	TnI # (ug/L)	TRIG (mg/dL)	CHOL (mg/dL)	AST (U/L)	ALT (U/L)	AST/ALT	TP (g/dL)	LDH (U/L)	CREA (mg/dL)	Urea (mg/dL)	UA (mg/dL)	BUN (mg/dL)
Acute	Saline (n = 15)	13039±1555)	915.9±61.5)	114.5±14.3)	38.8±2.0)	178.7±15.3)	57.1±3.0)	3.11±0.18)	71.4±0.9)	2507±224)	0.59±0.02)	35.0±1.8)	1.71±0.14)	16.3±0.9)
	DOX (n = 15)	12816±1564)	1053.0±83.7)	54.1*** ±4.2)	40.6±1.9)	341.0*** ±26.9)	137.8*** ±14.6)	2.64* ±0.15)	64.4*** ±0.9)	3055±271)	0.57±0.02)	34.5±1.3)	1.66±0.09)	16.1±0.6)
Sub-Chronic	Saline (n = 18)	9130±1007)	840.3±57.4)	126.9±8.9)	41.0±1.2)	183.1±10.6)	51.5±2.5)	3.63±0.20)	71.5±0.6)	4224±432)	0.64±0.01)	38.8±0.7)	1.63±0.12)	18.1±0.3)
	DOX (n = 18)	6262* ±709)	932.6±86.1)	376.3*** ±49.6)	93.1*** ±9.7)	139.6** ±5.0)	43.9* ±1.5)	3.20±0.10)	62.3*** ±0.9)	3561±497)	0.58** ±0.01)	33.7*** ±0.7)	1.39±0.09)	15.7*** ±0.3)

^#For troponin I analysis, only 13 and 16 samples were measured in acute and sub-chronic protocol, respectively due to limitations in the analytical kit used.

Differences between treatment groups means within the same model were evaluated by Student’s t test, when assumptions were not achieved a Welch correction or the non-parametric Mann-Whitney test were applied (see Material and Methods for detailed information).

^*p≤0.05;

^**p≤0.01;

^***p≤0.001 vs saline group of the same model. List of abbreviations: CK – creatine kinase; TnI – troponin I; TRIG – triglycerides; CHOL – total cholesterol; AST – aspartate aminotransferase; ALT – alanine aminotransferase; TP – total serum proteins; LDH – lactate dehydrogenase; CREA – creatinine; UA – uric acid; BUN – blood urea nitrogen; SE – standard error.