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. 2012 Jun 22;7(6):e39155. doi: 10.1371/journal.pone.0039155

Figure 3. Absence of hypersensitivity to LPS and splenomegaly in MyD88−/− mice after P. acnes treatment.

Figure 3

Groups of four to five WT, TLR9−/− and MyD88−/− mice were treated with heat-killed P. acnes (20 µg/g b.w.) i.v. or remained untreated (control). 7 and 21 days after priming the animals were challenged with LPS S.a.e. (0.01 µg/g b.w.) i.v. and plasma was collected two hours later for determination of IFN-αβ (A). The spleens were removed and weighted (B). One representative experiment of many is shown. *:p-value<0.05, **:p-value<0.01 and ***:p-value<0.001.