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. 2012 Jun 22;7(6):e39357. doi: 10.1371/journal.pone.0039357

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The hippocampus on the operated side of the brain was removed for miRNA expression profiling by deep sequencing at 24 hours (A, B) and 7 days (C, D) after CCI. Each circle represents a miRNA species. (A, C) The fold change (on log2 scale) of each miRNA species in CCI rats versus sham controls is plotted against its normalized read number (on log2 scale). (B, D) The p-value (on log10 scale) of each miRNA species is plotted against its fold change (on log2 scale). Blue and green dots are miRNAs that have p-values less than 0.05. (E, F) The fold change (on log2 scale) of miRNAs analyzed by qRT-PCR. Data are presented as mean ± s.e.m. Student’s t test was used for statistical analysis. * p<0.05; ** p<0.01.