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. 2012 Jun 22;7(6):e39298. doi: 10.1371/journal.pone.0039298

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Guo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The guinea pig IgH locus length is approximately 4,302 kb from the most 5′ V_H segment (V_H-290p) to the most 3′ end of α gene in genomic scaffold 54. Filled bars: potentially functional V_H genes; open bars: V_H pseudogenes and V-p; D_H: diversity genes; J_H: joining genes; μ: IgM coding gene; δ: IgD fragment; γ: IgG coding gene; ε: IgE coding gene and α: IgA coding gene. V_H and D_H genes are numbered based on the families and their order. The number before the dash (V_Hn) indicates the family, while the number after dash represents the genomic position. J_H genes are numbered based on the order of their locations in the locus. Double slashes indicate gaps >10 kb. The unidirectional arrowheads above δ gene segments in scaffold 54 indicate that its direction is opposite to the other heavy chain constant genes transcriptional direction. The scale does not apply the upper frame diagram.