. 2012 Jun 22;7(6):e39081. doi: 10.1371/journal.pone.0039081

Table 1. Changes in arterial blood gas during hypoxia and reoxygenation.

	Normoxic Baseline	2h of hypoxia		Reoxygenation with room air (minutes)
				10	25	40	60	120	240
pH
Sham-operated controls^†	7.40±0.03		7.42±0.03^*	7.43±0.04^*	7.44±0.03^*	7.44±0.04^*	7.43±0.05^*	7.43±0.04^*	7.43±0.06^*
Hypoxic-reoxygenated controls	7.42±0.06		6.98±0.08	6.95±0.10	7.07±0.07	7.14±0.06	7.20±0.06	7.33±0.06	7.32±0.06
Bicarbonate-treated group	7.40±0.03		7.00±0.06	6.98±0.10	7.13±0.08^*	7.23±0.06^*	7.28±0.07^*	7.38±0.06	7.37±0.05
PaO₂ (mmHg)
Sham-operated controls	78±23	69±6^*		67±4	68±3	68±7	58±9	66±3	64±3
Hypoxic-reoxygenated controls	78±20	35±6		76±9	82±17	76±17	67±7	67±8	67±11
Bicarbonate-treated group	68±11	35±7		79±20	78±12	81±18	74±19	68±8	66±8
PaCO₂ (mmHg)
Sham-operated controls	37±3	39±1		37±3^*	40±4	37±2	37±5	38±4	40±5
Hypoxic-reoxygenated controls	38±5	40±5		45±5	40±3	40±4	42±2	40±2	43±3
Bicarbonate-treated group	41±3	43±5		47±9	41±5	41±5	41±2	40±3	44±3
HCO₃− (mmol/L)
Sham-operated controls^†	23.3±2.1	25.6±1.7^*		26.0±1.7^*	26.4±2.9^*	25.3±2.7^*	25.0±2.7^*	25.9±2.6^*	26.0±2.7^*
Hypoxic-reoxygenated controls	24.6±1.9	8.2±1.6		8.6±1.8	10.9±1.8	12.9±2.0	15.3±2.2	20.8±2.7	21.2±3.4
Bicarbonate-treated group	24.8±1.7	8.9±1.7		9.4±1.9	12.9±2.3	16.4±2.4^*	18.7±3.0^*	22.9±2.6	24.5±2.9^*
Lactate (mmol/L)
Sham-operated controls^†	3.9±1.0	2.4±0.9^*		2.1±0.8^*	2.1±1.0^*	2.0±0.9^*	2.3±1.0^*	1.8±0.7^*	1.6±0.6^*
Hypoxic-reoxygenated controls	4.4±0.9	18.3±2.5		17.1±2.6	14.9±2.4	12.7±2.3	10.7±2.8	5.8±2.6	4.0±3.1
Bicarbonate-treated group	3.2±0.7	16.2±2.5		15.2±2.5	13.2±2.6	10.7±2.9	8.6±2.4^*	4.2±1.4	2.2±1.3

p<0.05 vs. hypoxic-reoxygenated control group at the corresponding time point (two-way repeated measures ANOVA).

^†

p<0.05 vs. hypoxic-reoxygenated control group (two-way repeated measures ANOVA).