Table 2. Changes in heart rate, mean arterial pressure and cardiac index during hypoxia and reoxygenation.
| Normoxic baseline | 2h ofhypoxia | Reoxygenation with room air (minutes) | |||||||||
| 10 | 25 | 40 | 60 | 120 | 240 | ||||||
| Heart rate (beat per minute) | |||||||||||
| Sham-operated controls | 206±8 | 205±33 | 202±29 | 204±26 | 208±26 | 206±34 | 200±32 | 201±28* | |||
| Hypoxic-reoxygenated controls | 170±19 | 200±18 | 203±35 | 207±19 | 217±26 | 218±28 | 221±23 | 232±52 | |||
| Bicarbonate-treated group | 175±24 | 199±20 | 225±30 | 223±25 | 216±26 | 211±25 | 210±31 | 232±57 | |||
| Mean arterial pressure (mmHg) | |||||||||||
| Sham-operated controls † | 66±8 | 59±7* | 57±6 | 57±8 | 58±8* | 58±7* | 56±9 | 53±8* | |||
| Hypoxic-reoxygenated controls | 83±15 | 30±3 | 63±20 | 49±10 | 46±8 | 47±7 | 49±8 | 42±10 | |||
| Bicarbonate-treated group | 81±10 | 28±2 | 59±10 | 48±6 | 43±5 | 42±4 | 48±5 | 44±7 | |||
| Pulmonary arterial pressure (mmHg) | |||||||||||
| Sham-operated controls | 25±3 | 25±2 | 26±3 | 26±3 | 27±2 | 28±1 | 26±4 | 24±3 | |||
| Hypoxic-reoxygenated controls | 26±4 | 32±4 | 38±5 | 33±4 | 32±4 | 30±3 | 27±3 | 29±4 | |||
| Bicarbonate-treated group | 27±5 | 31±5 | 39±7 | 34±6 | 31±5 | 29±5 | 29±7 | 29±5 | |||
| Cardiac index (ml/kg) | |||||||||||
| Sham-operated controls | 198±40 | 197±34* | 194±31 | 199±31 | 202±28 | 203±40 | 194±39* | 188±24* | |||
| Hypoxic-reoxygenated controls | 205±58 | 91±27 | 180±57 | 152±73 | 172±65 | 171±52 | 148±43 | 128±56 | |||
| Bicarbonate-treated group | 188±27 | 94±43 | 192±49 | 166±27 | 142±19 | 138±25 | 144±29 | 135±48 | |||
*
p<0.05 vs. hypoxic-reoxygenated control group at the corresponding time point (two-way repeated measures ANOVA).
†
p<0.05 vs. hypoxic-reoxygenated control group (two-way repeated measures ANOVA).