Table 3. Effects of bicarbonate on total glutathione (GSH), oxidized glutathione (GSSG), nitrotyrosine and lactate levels as well as superoxide dismutase (SOD) and catalase activities in cerebral cortex after hypoxic-reoxygenation.

Group	Group			p
	Sham-operated controls (n = 6)	Hypoxic-reoxygenated controls (n = 8)	Bicarbonate-treatedgroup (n = 8)
Total GSH (µmol/mg protein)	252±13*	158±20	146±11	0.001
GSSG (µmol/mg protein)	25±2	27±3	18±3	0.12
GSSG/total GSH ratio	0.10±0.01*	0.18±0.01	0.13±0.02	0.02
Nitrotyrosine (nmol/mg protein)	37±7*	93±22	62±9	0.05
Lactate (µmol/mg protein)	1.81±0.70	2.32±0.45	1.79±0.55	0.11
SOD (units/mg protein)	196±31	209±30	173±37	0.12
Catalase (nmol/min/mg protein)	1.18±0.60	0.72±0.42	0.97±0.32	0.18

^*p<0.05 vs. hypoxic-reoxygenated control group (one-way ANOVA).