Figure 2.
(a) Fitting of myoinositol/creatinine levels in the right posterior cingulated gyrus resulted in a significant improvement when modeled with a two-loci model compared to a single, main-effects model (Ppermuted<0.05). (b) Fitting of myoinositol/creatinine levels in left posterior cingulate gyrus resulted in a significant improvement when modeled with a two-loci model compared with a single, main-effects model (Ppermuted<0.05). (c) Fitting of choline/creatinine levels in the right medial cingulate gyrus resulted in a significant improvement when modeled with a two-loci model compared with a single, main-effects model (Ppermuted<0.05). (d) Results for question 18 on the SWAN scale (hyperactive question; ‘butting into conversations') and response to methylphenidate demonstrates significant two locus model effect compared with single locus effects (Ppermuted=0.0036). In all, 82 individuals from the USA1 sample were included. The y-axis represents improvement in the symptom after taking stimulant medication. The iad coefficient for an interaction between an additive effect from chromosome 4 and a dominant effect from chromosome 11 indicated the better fitting model (P=0.027).