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. 2012 May;13(3):245–251. doi: 10.2174/138920212800543093

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©2012 Bentham Science Publishers

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (3). Hox1 expression as a result of a multiscale action — Top: A macroscopic concentration gradient where the threshold T1 determines the domain of space-time signals for Hox1 activation along the anterior-posterior axis.

Center (right): The signals are transduced inside the (microscopic) nucleus. A pulling force F1 is generated that activates Hox1. Bottom: Collective gene activation leads to the macroscopic Hox1 expression along the anterior-posterior axis.