Fig. 3.

Changes in HDAC activity in mouse nuclei after ONC. a Total nuclear HDAC activity in control (OD) and experimental (OS) retinas after ONC. Crush retinas exhibit a slow progressive increase in nuclear HDAC activity relative to unaffected eyes. All activity can be inhibited by the broad002Dspectrum inhibitor TSA. b HDAC2 and HDAC3 localization after ONC. HDAC2 is predominantly present in the nuclear fraction of both control and crush retinas. HDAC3, however, redistributes to the nuclear fraction in crush eyes, consistent with the increase in nuclear HDAC activity after crush. Reprinted from [21], which is an open access journal