| Robotics Compared to Laparoscopy: Prostate Cancer | ||||||
|---|---|---|---|---|---|---|
| Outcomes | Illustrative comparative risks* (95% CI) |
Relative effect (95% CI) | No of Participants (studies) |
Quality of the evidence (GRADE) | Comments** | |
| Assumed risk | Corresponding risk | |||||
| Laparoscopy | Robotic | |||||
| Transfusions | Study population | OR 0.54 (0.3 to 0.95) |
1382 (5 studies) | □□⊖⊖ low |
RB > LP | |
| 53 per 1000 | 29 per 1000 (17 to 50) | |||||
| Medium risk population | ||||||
| 25 per 1000 | 14 per 1000 (8 to 24) | |||||
| Complications | Study population | OR 0.62 (0.25 to 1.53) |
1452 (5 studies) | □□⊖⊖ low1 |
n/a | |
| 204 per 1000 | 137 per 1000 (60 to 282) | |||||
| Medium risk population | ||||||
| 147 per 1000 | 97 per 1000 (41 to 209) | |||||
| Positive Surgical Margins | Study population | OR 1.09 (0.66 to 1.78) |
572 (4 studies) | □□⊖⊖ low |
n/a | |
| 134 per 1000 | 144 per 1000 (93 to 216) | |||||
| Medium risk population | ||||||
| 127 per 1000 | 137 per 1000 (88 to 206) | |||||
| Erectile Dysfunction | Study population | OR 0.76 (0.3 to 1.89) |
96 (1 study) | □□⊖⊖ low |
n/a | |
| 289 per 1000 | 236 per 1000 (109 to 434) | |||||
| Medium risk population | ||||||
| 289 per 1000 | 236 per 1000 (109 to 434) | |||||
| Urinary Incontinence | Study population | OR 0.6 (0.19 to 1.92) |
150 (1 study) | □□⊖⊖ low |
n/a | |
| 107 per 1000 | 67 per 1000 (22 to 187) | |||||
| Medium risk population | ||||||
| 107 per 1000 | 67 per 1000 (22 to 187) | |||||
| Blood Loss | The mean blood loss in the intervention group was 167.79 lower (231.67 to 103.91 lower) | 536 (4 studies) | □□⊖⊖ low |
RB > LP | ||
| Operation Time | The mean operation time in the intervention group was 0.13 lower (0.59 lower to 0.34 higher) | 536 (4 studies) | □□⊖⊖ low2 |
n/a | ||
| Length of Hospitalization | The mean operation time in the intervention group was 0.38 lower (0.91 lower to 0.14 higher) | 356 (2 studies) | □□⊖⊖ low |
n/a | ||
| Catheterization Duration | The mean operation time in the intervention group was 0.50 lower (1.01 lower to 0 higher) | 356 (2 studies) | □□⊖⊖ low |
Borderline effect | ||
| Anastomotic Stricture | Study population | OR 0.49 (0.02 to 10.26) |
288 (1 study) | □□⊖⊖ low |
n/a | |
| 10 per 1000 | 5 per 1000 (0 to 94) | |||||
The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
RB > LP indicates that robotics had a more favourable profile for the specific outcome; RB < LP indicates robotics had a less favourable profile for the specific outcome.
CI: Confidence interval; OR: Odds ratio; RB: Robotics; LP: Laparoscopy.
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.
Odds ratios cover <1 and >1, with previous surgical skill likely contributing.
Mean differences cover negative and positive values, with previous surgical skill likely contributing.