Table 1. Summary of References for Recent Studies Regarding the Role of Notch in T Cell Immune Responses.
| APC | Notch ligand | Notch receptor | In vivo model | Usage | Reference | |
|---|---|---|---|---|---|---|
| Th1 | DC (BM) | Dll4 | No | LPS treatment | [21] | |
| plate-bound Dll1-Fc | Dll1 | Notch 3 | Yes (Leishmania major) | DII1-Fc injection into L. major-infected mice | [22] | |
| DC (BM) | Dll4 | Yes (RSV) | MyD88-deficient mice | [28] | ||
| Dll1 or Dll4 retrovirus-transduced IL-12−/− DCs | Dll1 Dll4 | No | Forced expression of Dll | [29] | ||
| Jagged1-Fc and Delta1-Fc-fusion2 proteins | Dll1 Jagged1 | Yes (EAE) | In vivo blockade of Jagged1 and Dll1 | [30] | ||
| CD8− DCs (spleen) | Dll4 | No | LPS treatment | [31] | ||
| Notch 1 | Yes (EAE) | GSI inhibitor treatment | [32] | |||
| Notch 3 | Yes (EAE) | In vivo blockade of Notch 3 | [33] | |||
| Macrophage | Dll1 | Yes (influenza virus) | In vivo blockade of Dll1 | [34] | ||
| DC (BM) | Dll4 | Yes (RSV) | In vivo blockade of Dll4 | [35] | ||
| Th2 | DC (BM) | Jagged1 | Notch 1 | No | LPS treatment | [21] |
| Yes (L. major) | Mice that lack Notch signaling in CD4+ T cells | [25] | ||||
| Notch 1 Notch 2 | No | RBP-J-deficient (RBPfl/−-CD4Cre) mice | [26] | |||
| Notch 1 | No | ROSA26-DNMAML mice with CD4-cre mice | [27] | |||
| DC (BM) | Jagged2 | No | Immunization of Schistosoma mansoni egg antigen | [36] | ||
| Th17 | DC (BM) | Dll4 | Yes (Mycobacterial granuloma) | TLR9-deficient mice and in vivo blockade of Dll4 | [37] | |
| Notch 3 | Yes (EAE) | In vivo blockade of Notch 3 | [33] | |||
| Treg | Dll1 Dll4 Jagged1 | Notch 1 | Yes (asthma) | CD4+ T cells expressing Foxp3 and membrane-bound TGF-β | [23] | |
| Notch 1 | Yes (autoimmune hepatitis) | Notch1 antisense mice | [38] | |||
| Lin−Sca-1+c-kit+ hematopoietic progenitor cells | Jagged2 | Notch 3 | Yes (autoimmune diabetes) | Adoptive transfer of hematopoietic progenitor cells into NOD mice | [39] | |
| CD8+ T | DC (BM) infected with a retrovirus encoding Dll1 | Dll1 | Notch 2 | No | Notch2f/fE8I-Cre+ mice | [40] |
| Notch 1 | No | Notch1 antisense mice | [41] | |||
| Dll1 | Notch 1 | Yes (asthma) | Administration of Dll1-Fc | [42] | ||
| Macrophage | Dll1 | Yes (influenza virus) | In vivo blockade of Dll1 | [34] | ||
| DC (BM) | Dll4 | Yes (RSV) | In vivo blockade of Dll4 | [35] | ||
| γδT cells | No | Hes-1-deficient mice | [43] |
BM, Bone marrow; NOD, nucleotide-binding oligomerization.