Table 1.
Maternal, fetal and placental weights and serum adiponectin and insulin concentrations
| Parameter | Control (n= 9) | fADN (n= 7) | P value |
|---|---|---|---|
| Maternal | |||
| Age at mating (weeks) | 13.2 ± 0.8 | 13.6 ± 0.9 | 0.711 |
| Pre-pregnancy weight (g) | 19.9 ± 0.5 | 20.0 ± 0.9 | 0.913 |
| Weight at E14.5 (g) | 28.7 ± 0.4 | 29.1 ± 0.7 | 0.644 |
| Weight at E18.5 (g) | 35.2 ± 0.4 | 36.0 ± 1.3 | 0.585 |
| Serum endogenous ADN (μg ml−1) | 12.0 ± 1.1 | 10.2 ± 0.6 | 0.166 |
| Serum recombinant ADN (μg ml−1) | ND (n= 8) | 44.6 ± 2.6 (n= 7) | |
| Serum insulin (pg ml−1) | 85.9 ± 0.7 | 85.7 ± 0.4 | 0.700 |
| Fetal | |||
| Litter size | 7.3 ± 0.4 | 8.3 ± 0.4 | 0.113 |
| Fetal weight (g) | 1.18 ± 0.04 | 0.96 ± 0.05* | 0.006 |
| Placenta weight (g) | 0.058 ± 0.002 | 0.052 ± 0.002 | 0.095 |
| Fetal/placental weight ratio | 20.4 ± 1.1 | 18.0 ± 1.5 | 0.199 |
Values are means ± SEM. Mice received infusion of full-length adiponectin (fADN) from E14.5 to E18.5. All serum measurements were non-fasting at E18.5. ND: not detectable. Endogenous adiponectin serum concentrations were determined by ELISA and levels of recombinant adiponectin by Western blot. All fetal variables were measured at E18.5. Statistical significance was determined using Student's unpaired t test;
*
P < 0.05 was considered significant.