Fig. 3.

Statistical analysis of the nuclear nano-morphology marker characterized by structure-derived optical path length (OPL) from the cell nuclei of wild-type mice and histologically normal (i.e., uninvolved) appearing intestinal epithelial cell nuclei from gender and age-matched ${\mathit{Apc}}^{\mathrm{Min}}$ mice at six weeks and 4.5 months. The nuclear OPL exhibits a progressive increase with the development of carcinogenesis. Approximately 50 to 60 cell nuclei were analyzed from each mouse.