Fig. 7.

Statistical analysis of the nuclear optical path length (OPL) from the nuclei of intestinal epithelial cells in the ${\mathit{Apc}}^{\mathrm{Min}}$ mice with regular diet and with sulindac supplement. The progression of nuclear OPL in the histologically normal (i.e., uninvolved) intestinal epithelial cell nuclei significantly slowed down after 4-month of sulindac treatment ($P=0.3$) compared to the corresponding untreated ${\mathit{Apc}}^{\mathrm{Min}}$ mice ($P=1E-5$). The nuclear OPL from sulindac-treated mice is significantly lower than those untreated ${\mathit{Apc}}^{\mathrm{Min}}$ mice ($P=4.7E-5$). Approximately 50 to 60 cell nuclei were analyzed from each mouse.