Table 4: CARE-HF Results: Hemodynamic Values*.
| Variable | Difference in Means at 3 Months † (95% CI) |
P | Difference in Means at 18 Months (95% CI) |
P |
|---|---|---|---|---|
| Heart rate (beats/min) | +1.1 (-1.2–3.4) | .33 | +1.0 (-1.5–3.6) | .43 |
| Systolic blood pressure (mm Hg) | +5.8 (3.5–8.2) | < .001 | +6.3 (3.6–8.9) | < .001 |
| Diastolic blood pressure (mm Hg) | +1.5 (0.1–2.9) | .03 | +1.3 (-1.8–4.4) | .42 |
| Interventricular mechanical delay (msec) | -21 (-25 to -18) | < .001 | -21 (-25 to -17) | < .001 |
| Left ventricular ejection fraction (%) | +3.7 (3.0–4.4) | < .001 | +6.9 (5.6–8.1) | < .001 |
| ~4% of patients had EF increase to ≥ 0.35 | ~20% of patients had EF increase to ≥ 0.35 | |||
| Left ventricular end-systolic volume index (mL/m2) | -18.2 (-21.2 to-15.1) | < .001 | -26.0 (-31.5 to-20.4) | < .001 |
| Mitral regurgitation area (cm2) | -5.1 (-7.3 to -2.8) | < .001 | -4.2 (-7.0 to -1.4) | .003 |
†
“+” sign indicates a greater value; “-” sign, a smaller value in the CRT group than in the medical therapy group.
*
Cleland JGF, Daubert J, Erdmann E, Freemantle N, Gras D, Kappenberger L et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure (CARE-HF). New England Journal of Medicine 2005; 352:1539-1549; Copyright 2005 Massachusettes Medical Society. All rights reserved. (10)