Table 1. Observed Adverse Effects of Either Silenced or Augmented Cannabinoid/Endocannabinoid Signaling during Pregnancy in Mice.
cannabinoid
signaling |
|||
---|---|---|---|
silenced | optimal | augmented | |
pregnancy events | Cnr1–/– | WT | Faah–/– |
embryo development | retarded | normal | retarded |
oviductal embryo transport | retention | on time | retention |
blastocyst competency | conducive to competency | impediment to competency | |
uterine receptivity | suboptimal | receptive | suboptimal |
fetoplacental development | retarded/resorption | healthy | retarded/resorption |
parturition | preterm | full term |