Skip to main content
. 2011 Dec 9;3(2):96–104. doi: 10.1021/cn200083m

Figure 7.

Figure 7

Effect of Picrotoxin on the GABA-elicited currents modulated by DA and 5-HT. (A) Sample records showing that Ptx reversibly blocked the currents generated by 3.5 μM GABA and modulated by 210 μM DA and 340 μM 5-HT. Note that the coapplication of the biogenic amines and Ptx did not enhance the inhibitory effect. (B) Picrotoxin antagonism of the currents elicited by coapplication of GABA and either DA or 5-HT. The currents were normalized to the maximum amplitude elicited by GABA+DA or GABA+5HT in absence of Ptx. Data points are the means ± SEM from at least 8 oocytes (n = 8) from 5 frogs (N = 5).