Figure 8.

Lanthanum modulation. (A) Sample records illustrating the activation of GABAρ1 receptors and the potentiation of GABA-currents by La³⁺ and their modulation by DA and 5-HT. (B) La³⁺ concentration–response relations of the currents generated by 3.5 μM GABA and modulated by 210 μM DA and 340 μM 5-HT. Observe the blocking effect of DA and 5-HT on the GABA-elicited current in presence of La³⁺. The currents were normalized to the amplitude of that elicited by 3.5 μM GABA alone. Data points are the means ± SEM from at least 8 oocytes (n = 8) from 5 frogs (N = 5).