Figure 9.
Zinc inhibition. (A) Inhibition of the currents elicited by GABA alone and modulated by DA and 5-HT. The coapplication of either DA or 5-HT with Zn2+ enhances the inhibitory effect. (B) Concentration–response relationships of the currents elicited by 3.5 μM GABA and modulated by 210 μM DA and 340 μM 5-HT. Note the displacement of the curves in the presence of DA or 5-HT. The currents were normalized to the amplitude of that elicited by GABA+DA or GABA+5HT in absence of Zn2+. Data points are the means ± SEM from at least 7 oocytes (n = 7) from 5 frogs (N = 5).