Fig. 3.

Responses to GABA are smaller in AD. (A) Sample currents elicited by 1 mM GABA in oocytes injected with membranes from an AD brain (AD13) or a control brain (C3). (B) Box plot of specific GABA current per case grouped by diagnosis of control or AD. Each point is the specific GABA current of a single case. The AD group (n = 12 cases, 186 oocytes) gave smaller responses than the control group (n = 13 cases, 222 oocytes). Whiskers above and below the boxes indicate the 95th and fifth percentiles. (C) Plot of the specific GABA currents vs. age. Solid line is the linear regression fit to data from the control group and the broken line is for the AD group.