Fig. 4.
Comparison between GABA and AMPA-type receptors. (A) The mRNA ratios of the GABAAR-subunit γ2 to the GluR2 and GluR3 subunits (γ2/GluR2 and γ2/GluR3) were lower in the AD group, indicating that in AD the γ2 mRNA is down-regulated more than the GluR2 mRNA (n = 9 ADs, n = 7 controls). (B) Sample currents elicited by 1 mM glutamate plus 10 μM CTZ in oocytes injected with membranes from one control (C3) and one AD (AD3) cases. CTZ was preincubated for 80 s to get maximal response to glutamate. (C) The mean GABA/(Glu plus CTZ) ratio of the AD group, although smaller than the control, was not statistically significant (n = 12 ADs, 106 oocytes; n = 11 controls, 119 oocytes).