Skip to main content
. 2012 Jun 4;109(25):9995–10000. doi: 10.1073/pnas.1206493109

Fig. 3.

Fig. 3.

Consequences of sEH deletion/inhibition on progenitor cell mobilization. (A) CFU-C colony formation by PBMCs from WT and sEH−/− mice under basal conditions and following treatment with G-CSF (5 d). (B) Percentage of Lin−Sca-1+c-Kit+ cells derived from peripheral blood following treatment with G-CSF (5 d). (C) Spleen colony formation 12 d after transplantation of WT mice with PBMCs from G-CSF-treated WT or sEH−/− animals. (D) CFU-C colony formation by PBMCs from WT mice treated with vehicle (Veh) or the sEH inhibitor (sEH-I) t-AUCB under basal conditions and after treatment with G-CSF. (E) Cell invasion into Matrigel plugs impregnated with either solvent (PBS) or SDF-1. Animals were treated with either vehicle or G-CSF (5 d). Images were taken after sectioning and immunostaining of Matrigel plugs for CD31 (red) and α-actin (green) 9 d after implantation. The graphs summarize data obtained with 5–10 animals per group; *P < 0.05, **P < 0.01, ***P < 0.001.