Figure 2. The minimal connected network of TFs regulated in cancer cell lines.

The Snow web tool identified a significant human curated protein-protein interaction subnetwork involving 70 out of the 88 TFs correlatively regulated in cancer cell lines. The first connected component as shown here is considered as the minimal connected network (MCN) connecting these TFs. Each node represent a protein. Edges are the protein-protein interactions validated by at least two experimental evidences. Nodes shaded in violet represent the top ten most central TFs in the MCN. Node-ranking was based on the betweenness centrality scores.