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Inhibition of JNK activation does not affect T cell resistance to Dex. Dex-treated and control murine naive CD4+ T cells were stimulated for 3 days with (a) anti-CD3 plus IL-2 or (b) anti-CD3 plus anti-CD28 in the presence of 10 μM (max) or 5 μM (half) of SP600125. T cell proliferation was assessed by measuring 3H incorporation. Results are expressed as mean counts per minute (± SD) of triplicate cultures.
