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Removal of IL-6 expression in DPPI–/– mice abolishes the survival advantage. DPPI–/– mice (n = 46), DPPI–/–/IL-6–/– double-knockout mice (n = 45), DPPI+/+ mice (n = 40), and IL-6–/– mice (n = 27) were subjected to CLP, and survival was monitored for 5 days. Note that survival of DPPI–/–/IL-6–/– mice is significantly worse than that of DPPI–/– mice. *P = 0.001 for DPPI–/– vs. DPPI–/–/IL-6–/– mice, and P = 0.008 for DPPI–/– vs. DPPI+/+ mice.
