Figure 7. Halothane binding in the colchicine-binding pocket.

Blue – loop αT5, Red - strand βS9, Yellow – loop βT7 and helix βH8, Green – strand βS8, Orange – αE71, αN101, and βC241. (A) Colchicine binding site. (B) Halothane binding site 38, -2.72 kcal/mol, surrounded helix βH8 and strand βS8. (C) Halothane binding site 7, -3.13 kcal/mol, within 3 Å of βC241 and surrounded by strand βS9 and loop βT7.