Figure 8. Halothane binding in the vinblastine-binding pocket.

Red - loop αT7, Yellow – helix αH10, Green – strand αS9, Blue – loop βT5, Orange – helix βH6 and loop βH6-βH7. (A) Vinblastine binding site. (B) Halothane binding at site 21, −2.85 kcal/mol, within 2 Å of βY210 and surrounded by βH6 and βH7. (C) Halothane binding at site 39, −2.44 kcal/mol, within 5 Å of αK352 and βD179. (D) Halothane binding at site 1, −3.04 kcal/mol, within 3 Å of βD177 and surrounded by βT5.