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Peribronchial trichrome stain in WT and IL-5–deficient mice repetitively challenged with OVA. In the absence of OVA challenge, WT (a) and IL-5–deficient mice (c) exhibited minimal peribronchial trichrome staining (blue color). In contrast, repetitive OVA challenge in WT mice for 3 months induced circumferential peribronchial trichrome staining (b), which was significantly reduced in IL-5–deficient mice repetitively challenged with OVA (d).
