Fig. 4.

a Matrix displacement by WT SMCs in the presence (n = 11) versus absence (n = 10) of 5 μM of the transglutaminase active site inhibitor L682777. While L682777 had no significant effect on displacement of the innermost circle, compaction between 100 and 200 μm was absent, resulting in statistically significant reduction of displacement that became larger towards the outer rings. b Local strain under both conditions. c Dynamics of matrix displacement for the outermost ring (307 μm) reveal that this process is slower in the presence of the blocker, and comes to a stand-still after ~5 h, while it continuous for ~12 h in control. d Displacement dynamics for the various distances