Fig. 6.

Experimental overview of macroscopic compaction of a collagen matrix. a A ring-shaped collagen gel was casted using a Teflon mold in an ultra-low binding multiwell plate; the pictures display the gel at the start and after 6 h of cell-induced compaction, when the gels develop a doughnut shape. b Macroscopic compaction, quantified as changes in the inner or outer perimeter of the gel, was not dependent on the TG2 active site inhibitor L682777. n = 9 for both groups. c Macroscopic compaction in gels that remained flat