Table 3.
Diagnostic sensitivity and specificity in percentage at 95% confidence interval of serum M2-pyruvate kinase using various cut-off value settings for different colorectal lesions compared with 158 normal people in colorectal cancer mass screening in Hangzhou, 2006-2008 (95% CI)
| M2-PK (U/mL) |
Colorectal cancer |
Advanced adenoma |
Adenoma |
Non-adenomatous polyp |
||||
| Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | |
| 2.00 | 100.00 (100.00-100.00) | 40.51 (32.85-48.16) | 95.12 (88.53-100.00) | 40.51 (32.85-48.16) | 82.48 (76.12-88.85) | 40.51 (32.85-48.16) | 82.98 (72.23-93.72) | 40.51 (32.85-48.16) |
| 2.50 | 94.62 (90.04-99.21) | 55.06 (47.31-62.82) | 85.37 (74.55-96.18) | 55.06 (47.31-62.82) | 71.53 (63.98-79.09) | 55.06 (47.31-62.82) | 76.60 (64.49-88.70) | 55.06 (47.31-62.82) |
| 3.00 | 91.40 (85.70-97.10) | 65.19 (57.76-72.62) | 75.61 (62.46-88.75) | 65.19 (57.76-72.62) | 61.31 (53.16-69.47) | 65.19 (57.76-72.62) | 65.96 (52.41-79.50) | 65.18 (57.76-72.62) |
| 3.50 | 87.10 (80.28-93.91) | 68.99 (61.78-76.20) | 73.17 (59.61-86.73) | 68.99 (61.78-76.20) | 56.93 (48.64-65.23) | 68.99 (61.78-76.20) | 55.32 (41.11-69.53) | 68.99 (61.78-76.20) |
| 4.00 | 81.72 (73.87-89.58) | 74.05 (67.22-80.89) | 65.85 (51.34-80.37) | 74.05 (67.22-80.89) | 49.64 (41.26-58.01) | 74.05 (67.22-80.89) | 48.94 (34.64-63.23) | 74.05 (67.22-80.89) |
M2-PK: M2-pyruvate kinase.