Table 4.
Positive predictive value and negative predictive value in percentage at 95% confidence interval of serum M2-pyruvate kinase using various cut-off value settings for different colorectal lesions compared with 158 normal people in colorectal cancer mass screening in Hangzhou, China, 2006-2008 (95% CI)
| M2-PK (U/mL) |
Colorectal cancer |
Advanced adenoma |
Adenoma |
Nonadenomatous polyps |
||||
| PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | |
| 2.00 | 49.73 (42.57-56.90) | 100.00 (100.00-100.00) | 29.32 (21.59-37.06) | 96.97 (92.83-100.00) | 54.59 (47.81-61.37) | 72.73 (63.42-82.03) | 29.32 (21.59-37.06) | 88.89 (81.63-96.15) |
| 2.50 | 55.35 (47.62-63.07) | 94.57 (89.93-99.20) | 33.02 (24.07-41.97) | 93.55 (88.56-98.54) | 57.99 (50.55-65.43) | 69.05 (60.98-77.12) | 33.64 (24.69-42.60) | 88.78 (82.23-95.03) |
| 3.00 | 60.71 (52.62-68.80) | 92.79 (87.98-97.60) | 36.05 (25.90-46.19) | 91.15 (85.91-96.39) | 60.43 (52.30-68.56) | 66.03 (58.59-73.46) | 36.05 (25.90-46.19) | 86.55 (80.43-92.68) |
| 3.50 | 62.31 (53.98-70.64) | 90.08 (84.76-95.41) | 37.97 (27.27-48.68) | 90.83 (85.67-96.00) | 61.42 (52.95-69.88) | 64.88 (57.66-72.10) | 34.67 (23.90-45.44) | 83.85 (77.52-90.17) |
| 4.00 | 64.96 (56.31-73.60) | 87.31 (67.22-80.89) | 39.71 (28.08-51.34) | 89.31 (84.02-94.60) | 62.39 (53.29-71.48) | 62.90 (55.96-69.85) | 35.94 (24.18-47.69) | 82.98 (76.78-89.18) |
M2-PK: M2-pyruvate kinase; PPV: Positive predictive value; NPV: Negative predictive value.