Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jul;140(1):17–28. doi: 10.1085/jgp.201210801

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Jadey and Auerbach

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — Activation of AChRs by CCh. (A) Low resolution view of current clusters that reflect binding and gating activity of single AChRs (+70 mV; open is up). (B) Higher resolution view of clusters at different [CCh] and corresponding intra-cluster interval duration histograms. Solid lines are the global fit by boxed states in D. (C) With increasing [CCh], the effective opening rate reaches a plateau that is the diliganded opening rate constant. (D) Cyclic model for binding and gating. R, LA/closed-channel conformation; R*, HA/open-channel conformation; A, agonist; K_d, equilibrium dissociation constant of R; J_d, equilibrium dissociation constant of R*. E₀, E₁, and E₂ are gating equilibrium constants with zero, one, and two bound agonists. When the two binding sites are functionally equivalent, E₂/E₀ = (K_d/J_d)² and E₁/E₀ = E₂/E₁. The rate constants: k_on, LA association; k_off, LA dissociation; f₂, diliganded opening; b₂, diliganded closing. (E) Agonist structures.