Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jul;140(1):41–53. doi: 10.1085/jgp.201210796

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Telezhkin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Effect of incremental DiC₈-PI(4,5)P₂ concentrations on homomeric Kv7.2 and Kv7.3 channel activity. (A and B) Examples of multichannel recordings in excised membrane patches from HM1-CHO cells transfected with cDNAs for Kv7.2 and Kv7.3^T cDNAs. C, closed state; O1–On, open-state current levels for 1 to n channels, as indicated. Holding potential is 0 mV. (C) Mean (±SEM) single-channel open probability corrected for the number of channels in each patch plotted against DiC₈-PI(4,5)P₂ concentrations. Triangles represent Kv7.2; squares represent Kv7.3^T. Curves show data fits to single-component Hill equations giving the parameters shown. The interrupted line shows the two-component fit from Fig. 2 obtained from K2/3-CHO cells stably expressing Kv7.2 + Kv7.3 subunits.