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. 2012 Jul;140(1):41–53. doi: 10.1085/jgp.201210796

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© 2012 Telezhkin et al.

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Figure 4. — Effect of incremental DiC₈-PI(4,5)P₂ concentrations on heteromeric Kv7.2/Kv7.3(EEE) channel activity. (A) Responses of a cluster of seven channels expressed from cotransfected Kv7.2 and Kv7.3(EEE) cDNAs to incremental concentrations of DiC₈-PI(4,5)P₂. C, closed state; O1–O7, open-state current levels for 1–7 channels, as indicated. Holding potential is 0 mV. (B) Mean (±SEM) single-channel open probability of 13 patches corrected for the number of channels in each patch plotted against DiC₈-PI(4,5)P₂ concentrations. The curve shows data fit to a single-component Hill equation (solid line). The interrupted line shows the two-component fit to data from coexpressed Kv7.2 + Kv7.3 subunits, illustrated in Fig. 2.