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DNA damage response to genotoxin or telomere dysfunction in cells lacking either Wrn or p16Ink4a function. (A) Western blot analysis to determine the response of MEFs to doxorubicin treatment; (B) Western blot analysis to determine the response of MEFs to TRF2ΔBΔM overexpression. Wild type MEFs (WT) were used as controls; (C) SA-β-Gal staining of p16Ink4a−/−, Wrn−/− and p16Ink4a−/−Wrn−/− MEFs following TRF2ΔBΔM overexpression.
