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Schematic representation of p160MBP repression of PGC-1α on DNA; regulation by p38 MAPK signaling events. p160MBP binds to PGC-1α and represses transcription of PGC-1α target genes. On cytokine or β-adrenergic signaling, p38 MAPK becomes active and phosphorylates PGC-1α. The phosphates disrupt p160MBP binding to PGC-1α, leading to increased activation of PGC-1α target genes.
