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. 2012 May 23;13(5):6407–6423. doi: 10.3390/ijms13056407

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Inhibition effects of Ecklonia cava enzymatic extract and its isolated compounds on 5α-reductase activities. (A-E) Assay of 5α-reductase inhibition was performed using a crude extract of rat prostate. The reaction mixture contained [1,2,6,7-³H] testosterone, prostatic enzyme and E. cava enzymatic extract or its isolated compounds (eckol, dieckol, phloroglucinol and triphlorethol-A). The conversion rate of testosterone (T) to dihydrotestosterone (DHT) was calculated by the equation [DHT/(T + DHT)]. Inhibition activity (%) was expressed as a percentage of reduced conversion rate compared to the control. The inhibition activity of control group was regarded as 0% (not shown). Finasteride was used as a positive control. Data are presented as the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. finasteride; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. control.

Inhibition effects of Ecklonia cava enzymatic extract and its isolated compounds on 5α-reductase activities. (A-E) Assay of 5α-reductase inhibition was performed using a crude extract of rat prostate. The reaction mixture contained [1,2,6,7-³H] testosterone, prostatic enzyme and E. cava enzymatic extract or its isolated compounds (eckol, dieckol, phloroglucinol and triphlorethol-A). The conversion rate of testosterone (T) to dihydrotestosterone (DHT) was calculated by the equation [DHT/(T + DHT)]. Inhibition activity (%) was expressed as a percentage of reduced conversion rate compared to the control. The inhibition activity of control group was regarded as 0% (not shown). Finasteride was used as a positive control. Data are presented as the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. finasteride; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 vs. control.