Fig. 4.

Model predicted and observed concentrations of vinpocetine in plasma after oral administration in male Wistar rats. One-compartment model for vinpocetine solution and two compartment model for vinpocetine solid-lipid nanoparticles. ka, absorption rate constant from GI tract to the plasma; kel, elimination rate constant from the plasma compartment; k12, rate constant for transfer of drug from the plasma compartment to the distribution compartment; k21, rate constant for transfer of drug from the distribution compartment to the plasma compartment.