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Dose-response inhibition of 5.0 μM [3H]GlySar uptake by oseltamivir (0.5–200 mM) in P. pastoris expressing human (pPIC3.5K-hPept1), mouse (pPIC3.5K-mPept1), and rat (pPIC3.5K-rPept1) PEPT1 and vector control (pPIC3.5K). The 30-s uptakes were obtained at 24°C using pH 6.5. buffer. Data are expressed as means ± S.E. (n = 6). Solid lines were generated using the fitted parameters in Table 6, and the dashed line represents 100% of control.
