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. 2004 Feb 1;18(3):320–332. doi: 10.1101/gad.1162204

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Copyright © 2004, Cold Spring Harbor Laboratory Press

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Figure 2. — Inactivation of Ovca1 or Ovca1-2 causes developmental abnormalities. Gross morphology of E18.5 (A) wild-type and (B) Ovca1-2^-/- pups. Ventral view of palate of E18.5 (C) wild-type and (D) Ovca1-2^-/- mice, showing cleft palate in the mutant (arrow). (E,F) H&E-stained histological sections of lung from E18.5 wild-type (E) and Ovca1-2^-/- (F) pups. (G) E10.5-E11.5 embryos. E10.5 wild-type embryo (left); E11.5 wild-type embryo (second from left); two E11.5 Ovca1-2^-/- embryos (right). (H) E9.5 embryos. Wild-type embryo (left); two Ovca1-2^-/- embryos (right). (I) E8.5 embryos. Wild-type embryo (left); Ovca1-2^-/- embryo (right). (J) E14.5 embryos. Wild-type embryo (left); Ovca1^-/- embryo (right) with edema (arrow). (K) E13.5 Ovca1-2^-/- embryo with midbrain exencephaly (arrow). (L) Hindlimb of an E14.5 wild-type embryo. (M) Preaxial polydactyly (arrow) in right hindlimb of E14.5 Ovca1-2^-/- embryo. (N,O) H&E-stained histological sections of E16.5 fetal liver from wild-type (N) and Ovca1-2^-/- (O) embryos. The mutant liver is highly basophilic and has a focal area of necrosis (arrow). (P,Q) Representative Wright-Giemsa-stained blood smears of E16.5 wild-type (P) and Ovca1-2^-/- or Ovca1^-/- (Q) embryos. Note that many of the mutant erythrocytes are nucleated.