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. 2004 Feb 1;18(3):320–332. doi: 10.1101/gad.1162204

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Copyright © 2004, Cold Spring Harbor Laboratory Press

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Figure 3. — Ovca1 mutant MEF cell cycle analysis and ovary grafts. (A) Growth dynamics of Ovca1 mutant MEFs. Genotypes are indicated in upper left corner: (Control) wild-type or Ovca1^+/-. (B) Histogram showing the percentage of the MEF population in G₁ (G₀/G₁), S, and G₂ (G₂/M). (C) Western blot showing RB and its phosphorylation (pRB) status in Ovca1 mutant MEFs. Analysis of passages 1 to 3 (P1, P2, P3) was derived from Ovca1^+/+ (+/+), Ovca1^+/- (+/-), and Ovca1^-/- (-/-) embryos. Analysis of MEFs at passage 4 (P4) was derived from embryos obtained from Ovca1^+/- × Ovca1-2^+/- matings. (D) Gross morphology of Ovca1-2^+/+ (+/+) and Ovca1-2^-/- (-/-) ovaries (arrows) grown under the kidney capsule for 1 mo. (E,F) Histology of wild-type and Ovca1-2^-/- ovary grafts shown in D. (G) Gross morphology of wild-type and Ovca1-2^-/- ovaries grown in the ovarian bursa for 3 mo. (Inset) Histology of the 3-mo-old Ovca1-2^-/- ovary graft. Corpus luteum (arrowhead) indicates ovulation. (H) Gross morphology of wild-type and Ovca1-2^-/- ovaries grown in the ovarian bursa for 9 mo.