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. 2004 Feb 1;18(3):320–332. doi: 10.1101/gad.1162204

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Copyright © 2004, Cold Spring Harbor Laboratory Press

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Figure 4. — Effect of p53-deficiency on Ovca1 mutant MEF growth and embryo development. (A) Growth dynamics of Ovca1 mutant MEFs. Genotypes are indicated in the upper left corner. (B) Percentage of S-phase cell population derived from MEFs with various Ovca1 and p53 genotypes. Two to three independent MEF lines were analyzed (Ovca1-2^+/+ p53^+/+, n = 2; Ovca1-2^+/- p53^+/+, n = 2; Ovca1-2^-/- p53^+/+, n = 3; Ovca1-2^+/+ p53^+/-, n = 2; Ovca1-2^+/- p53^+/-, n = 3; Ovca1-2^-/- p53^+/-, n = 3; Ovca1-2^+/- p53^-/-, n = 3; Ovca1-2^-/- p53^-/-, n = 3). (C) Gross morphology of E18.5 cis Ovca1-2^+/- p53^+/- pup (left) and Ovca1-2^-/- p53^-/- pups (two pups on the right; top); normal palate fusion was found in 50% of Ovca1-2^-/- p53^-/- pups (n = 4; representative shown at right) in comparison to cleft palate (arrow) found in 50% of the same genotype (n = 4, representative shown in the middle). Normal palate morphology of representative cis Ovca1-2^+/- p53^+/- littermate (n > 4) is shown at the left as a control.